Da Vinci’s Mona Lisa and Warhol’s Marilyn Monroe Paintings Essay

Leonardo DaVinci’s Mona Lisa is one of the most well-known paintings in the world. Show anyone from a 60 year old man to a 10 year old girl a picture of the painting and, most likely, they will be able to name the painting as well as the painter. While some say that DaVinci’s painting is the most famous of all created, many of Andy Warhol’s paintings are also easily recognizable. Almost everyone has seen the Campbell’s Soup Can series Warhol painted or his famous Triple Elvis print. This paper will be focusing on his Marilyn Monroe series, which I will be comparing and contrasting to the Mona Lisa. There are many obvious differences between the two paintings, such as the time period, color scheme, background and subject matter. My goal is to also point out some similarities such as their use of line, recreations, fame, and prominence in society. One of the major contrasts between the two works is the history behind the paintings. Andy Warhol was said to be fascinated with the actress Marilyn Monroe’s supposed suicide in August of 1962. Warhol proved the Proverb, â€Å"Good men must die, but death cannot kill their names† to be true, making his Marilyn Monroe series one of his most famous works. Warhol bought a publicity still of Marilyn’s 1953 movie Niagara, cropped it, enlarged the face, and reproduced it on eight different canvases. Each painting was given a different color scheme. These paintings were the first solo exhibition for Warhol. The most famous of the series, Lemon Marilyn, was bought and kept in a private collection until 2007. While the subject of Warhol’s painting is very well known and easily recognized, the subject of Leonardo DaVinci’s Mona Lisa was most likely commoner, and there are many different theories of who the woman could be. Some say the woman is DaVinci himself, in woman form. Others say it could be Lisa Gherardini; the wife of a wealthy businessman in Florence, Italy named Francesco Del Giocondo. DaVinci was commissioned to paint the Mona Lisa in 1503, and worked on it for four years before it was finished. DaVinci kept his painting for quite a while before he sold it to the King of France, King Francois, in 1516. (â€Å"Mona Lisa.† Lairweb.com. N.p., n.d. Web.) After the French Revolution, the painting was moved to the Louvre, where it remains today. The history behind the paintings also point out several more differences. There is only one Mona Lisa, while Warhol created many Marilyn paintings. The time period when the two painters lived was decades apart. DaVinci was alive from 1452-1519, while Warhol was born in 1928 and died in 1987. While Warhol was strictly an artist, DaVinci spent time as a mathematician, engineer, writer, and geologist as well. The two men’s styles of painting were very different as well. DaVinci painted in the style of chiaroscuro, the use of strong contrasts between light and dark, and sfumato. Sfumato is created by painting a color that turns slowly from light to dark tones to give off a kind of misty glow or smoky mystery. Andy Warhol was a major part of the Pop art movement. Jennifer Rosenberg of About.com quoted pop art as being, â€Å"a new style of art that began in England in the mid-1950s and consisted of realistic renditions of popular, and everyday items.† (Rosenberg, Jennifer. â€Å"Andy Warhol.† About.com 20th Century History. About.com, n.d. Web. 16 Dec. 2012.) Warhol used silk-screening to create Marilyn Monroe. Warhol is quoted as saying, â€Å"In August 62 I started doing silkscreens. I wanted something stronger that gave more of an assembly line effect†¦you pick a photograph, blow it up, transfer it in glue onto silk, and then roll ink across it so the ink goes through the silk but not through the glue†¦ I was thrilled with it. When Marilyn Monroe happened to die that month, I got the idea to make screens of her beautiful face the first Marilyns.† (â€Å"Andy Warhol’s Marilyn Prints.† Andy Warhol’s Marilyn Prints. Color Vision and Art, n.d. Web. 16 Dec. 2012.) DaVinci’s painting was progressive for the time. The traditional paintings of his time were of a head and shoulders portrait, in a very rigid or posed position. The Mona Lisa is painted all the way down to her hands, and she seems to be in a very comfortable, relaxed pose. Her pose is very linear, which conveys a sense of â€Å"formal and dignified ideas†. (ROEMER, CK. â€Å"Looking at Great Art Practice.† Http://www.studiocodex.com. N.p., 2007. Web.) This would be appropriate if this woman is the wife of a wealthy man, which is one of the speculations of the woman’s identity. Andy Warhol’s painting, on the other hand, seems almost regressive. Only Marilyn’s face is shown. She is depicted with a very serious expression, and is very unnaturally posed. This seems to project a sense of excitement or disorder, which represent Marilyn’s life very accurately. The two subjects of the painting are very different in appearance as well. The Mona Lisa has no makeup on. She is dressed very plainly and does not seem to be wearing any jewelry. Marilyn Monroe has a lot of make-up on and has her hair curled and styled. Marilyn seems to have a haughty or annoyed expression on her face, while Mona Lisa is smiling slightly and seems to be happy and content. Another major difference between the two paintings is the use of color. The Mona Lisa is depicted in very earthy tones. The tan color of the flesh seems closer to the viewer, while the muted browns, greens, tans, and blues seem to fade into the background. DaVinci used light and dark colors to highlight certain parts of the painting, such as the woman’s face and hands. The color palette is what would be expected if this was an actual photograph. Andy Warhol’s Marilyn is the complete opposite of the Mona Lisa. None of the colors are natural, except, maybe, the makeup, and can appear shocking to the eye at first glance. All aspects of the painting are bright; eyes, lips, eye shadow, and hair. Warhol painted Marilyn in ten different color combinations with 250 of each color variation. (Henry. â€Å"Henry On Pop Art.† ‘Henry On Pop Art’ N.p., 08 Aug. 2011. Web. 16 Dec. 2012.) While the actual colors used in the paintings are very different, the way the painters used the colors brings out a similarity in the two. Mona Lisa is dressed very dark and her pale face is framed by dark hair. The light colors used in the background seem to bring the woman to the front of the painting. This was most definitely done on purpose by DaVinci. He wanted the viewer to focus on Mona Lisa. The same can be said of Warhol. He uses a bright contrasting color for his background of Marilyn Monroe. Although the background color almost always matches that of Marilyn’s eye shadow, the background contrasts with the rest of the painting, bringing the face towards the viewer. The use of line in both paintings is also similar. No brush strokes are visible in either painting, and appear a bit foggy. The Mona Lisa is this way due to the technique, sfumato, discussed earlier. In Marilyn, it is hard to pick out a defined line in her hair, for example. The lines in DaVinci’s paintings are the same, flowing from one to the other. The Mona Lisa is blended so well that each section seems like a part of the next. The background of the Mona Lisa is a landscape with a river, bridge, trees, grass, and mountains. The view seems to go on forever, and there is no real focal point in the background. The backgrounds purpose in this painting in unknown, some say it is to contrast the peaceful look of the woman with a foreboding background. Others think it could have been as simple as DaVinci practicing with landscapes. Unlike Mona Lisa, the backgrounds of the Marilyn Monroe paintings are a solid color. The background contrasts dramatically with the colors in the actual face. The background pulls the viewer’s eye to Marilyn’s face, instead of something that could be happening in the background. Symmetry is another example of a way the two paintings are alike. The shape of the Mona Lisa is very symmetrical. The woman is sitting straight and a straight line down the middle of the painting would show equal parts. The woman’s body is a triangular shape, with the tops of her legs and hand forming the base, and her head becoming the point. Her face is very circular, and the smile she displays is an arch of a circle. (Roemer, CK. â€Å"Looking at Great Art Practice.† Http://www.studiocodex.com. N.p., 2007. Web.) Warhol gives his Marilyn Monroe paintings a subtle heart shape with the curves created by her hairline. The painter, like DaVinci, uses simple shapes as well, such as the half-moon of her eye shadow, or the slight triangles of her eyebrows, which also shows symmetry. DaVinci creates a feeling of depth and space in his painting. The fact that the woman is taller than the mountains in the background suggests that she is seated very close to the viewer, while the mountains are in the distance. The detail of the pleats in her skirt, the individual pieces of hair, and transparent veil that covers her head are small details that make the woman seem closer to the viewer. The walking paths and streams of water leading up the painting make the eye move upwards, and form a sense of continuous forest. The viewers understand that the landscape goes on for quite a while. (Roemer, CK. â€Å"Looking at Great Art Practice.† Http://www.studiocodex.com. N.p., 2007. Web.) In contrast to DaVinci, Warhol used space by placing Marilyn’s face in the middle of the painting. There is no real use of depth in this painting, because of the plain, contrasting color background. She almost appears to be completely flat against the surface. The eye is immediately drawn to the face in Marilyn Monroe. As mentioned above, the contrasting background color pulls the face forward, making the viewer notice her first. The same can be said of Mona Lisa, making focal point a similarity of the two. The woman in Mona Lisa is the biggest part of the painting. Her pale face offset by her dark hair and clothes draws the viewer’s eye to her. The position of her hands is right below her face, which also serves as a line to the focal point. The use of texture is somewhat absent from Warhol’s painting, while the Mona Lisa is full of texture, another difference in the paintings. The folds in the woman’s dress make the painting seem more realistic, while the uneven and sharp edges of the mountains in the background contrast nicely with the smoothness of the woman’s face and hair. The woman’s skin also has a dotted affect which makes it seem more lifelike, instead of Warhol’s Marilyn that seems fake and unrealistic. The use of value plays a huge role in both paintings. DaVinci uses abrupt changes in value; The pale skin of the woman face and hands against her dark hair and dress. He uses the same type of changes to show the wrinkles on the fabric of her clothing. (ROEMER, CK. â€Å"Looking at Great Art Practice.† Http://www.studiocodex.com. N.p., 2007. Web.) Andy Warhol uses value changes in the brightness of Marilyn’s hair against the darker background. The black tones used underneath her hair are darker than the color of her somewhat pale skin. Another similarity is the massive amounts of recreations or paintings based on the same subject. Many artists has done their own version of the Mona Lisa, making her their nationality, fat, and even making her another person altogether. Many artists have also taken Marilyn Monroe and painted her their own way. Both paintings still play a huge role in society today. You can buy phone cases, laptop skins, and even clothing with a picture of these paintings. Replicas of both paintings can be seen hanging on walls of homes, restaurants, and art galleries. Mona Lisa and Marilyn Monroe are both easily recognized and correctly identified in today’s society. A final similarity between the two paintings is the significance they both played in their style of art. Leonardo DaVinci’s Mona Lisa is said to have â€Å"become the prototype for Renaissance paintings.† (Lorenzzi, Rosella. â€Å"Mona Lisa.† Mona Lisa. N.p., 16 Jan. 2008. Web. 16 Dec. 2012.) Andy Warhol was affectionately known as the â€Å"Pope of Pop†, and his Marilyn Monroe series came to be one of the most well-known and popular works of pop art in his time. The final difference between the two, and most interesting, is that Warhol recreated DaVinci’s Mona Lisa in his own style; putting 30 Mona Lisas in one silk screen. Warhol is quoted as saying â€Å"30 is better than 1.† (Rose, Millie. â€Å"Postmodernism.† : Andy Warhol. N.p., 08 Nov. 2010. Web. 16 Dec. 2012.) The Mona Lisa is said to have been a major inspiration to Warhol, and he was honored to be able to have his own spin on this iconic painting. Obviously Warhol’s w ork did not influence DaVinci because of the time frame. While the differences far outweigh the similarities, both paintings are brilliant. Warhol was a major influence in the pop art world, and his paintings are still being used in many forms of advertising today. DaVinci is said to have been the ultimate example of what a portrait should be, and without a doubt, he has influenced many of the other famous painters today. Both men, while their styles couldn’t have been anymore different, have two of the most famous names in the art world. * Esaack, Shelly. â€Å"Lemon Marilyn, 1962.† About.com Art History. N.p., n.d. Web. 16 Dec. 2012. * â€Å"Mona Lisa.† Lairweb.com. N.p., n.d. Web. * Rosenberg, Jennifer. â€Å"Andy Warhol.† About.com 20th Century History. About.com, n.d. Web. 16 Dec. 2012. * Henry. â€Å"Henry On Pop Art.† ‘Henry On Pop Art’ N.p., 08 Aug. 2011. Web. 16 Dec. 2012. * ROEMER, CK. â€Å"Looking at Great Art Practice.† Http://www.studiocodex.com. N.p., 2007. Web. * Lorenzzi, Rosella. â€Å"Mona Lisa.† Mona Lisa. N.p., 16 Jan. 2008. Web. 16 Dec. 2012. * Rose, Millie. â€Å"Postmodernism.† : Andy Warhol. N.p., 08 Nov. 2010. Web. 16 Dec. 2012.

Company Overview of Domestic Direct Competitors of Sime Darby

COMPANY OVERVIEW OF DOMESTIC DIRECT COMPETITORS OF SIME DARBY (GENTING BERHAD) Genting Berhad (Genting), a holding company for the Genting Group, operates resorts, casino and plantations. It also develops properties, manufactures paper and generates electricity. The company primarily operates in Malaysia. It is headquartered in Kuala Lumpur, Malaysia and employs 36,000people. The company recorded revenues of MYR6,943. 8 million (approximately $1,968. 3 million) during the fiscal year ended December 2006, an increase of 27. 3% over 2005. The operating profit of the company was MYR3,124. million (approximately $885. 7 million) during fiscal year 2006, an increase of 22. 7% over 2005. The net profit was MYR2,242. 5 million in fiscal year 2006, an increase of 23. 8%over 2005. SWOT ANALYSIS Genting is the management and investment holding company of Genting Group. Through its subsidiaries, the company provides leisure and hospitality, cruise and entertainment businesses. Genting also oper ates plantations, develops and manages property, power generation, manufactures and trades paper, explores oil and gas and provides tours and travel related services.The continued success of its leisure and hospitality business, driven by a strong performance from Genting Highlands Resort and its gaming business, has improved overall revenue and profit growth for the company. However, regional competition from new leisure attractions such as Disneyland and Macau's strong position in the gaming business could weaken the company's leisure and hospitality business. Strengths †¢Diverse business portfolio †¢Strong leisure and hospitality division †¢Strong performance of oil and gasWeaknesses Weak performance of property and manufacturing divisions †¢Weak returns Opportunities †¢Growing wealth of Asian population †¢Government initiatives to promote Malaysia †¢Strong outlook for China’s energy sector †¢Rising demand for biodieselThreats †¢Intense competition †¢Natural disasters and epidemics †¢Weakening demand for residential housing STRENGTHS †¢Diverse business portfolio Genting has a diversified business portfolio, which includes the management of casinos and resorts, plantations, property development, paper manufacturing and power generation.Aided by strong growth in most of its business divisions in fiscal year 2006, Genting managed to record an increase of 27. 3% in its revenues over fiscal year 2005. The revenues from leisure and hospitality division increased 20. 9%; power 89. 1%; plantation 10%;and oil and gas 19. 8%. The company is not overly dependent on any one product or business division. Its diversified business portfolio protects it from downturns in any particular division and reduces business risk. †¢Strong leisure and hospitality division The company's leisure and hospitality division has continuously contributed the highest revenues for Genting.The leisure and hospitality divis ion operates the company's hotel, gaming and entertainment businesses. In fiscal year 2006, the division recorded revenues of MYR4,286. 9 million(approximately $1,215. 2 million), contributing 61. 7% to the company's revenues. This increase is mainly due to the higher volume of business from Genting Highlands Resort. For the period 2002-2006, the leisure and hospitality division grew at a CAGR of 12%. The division's strong performance is attributed to the overall success of the company's theme resorts which are becoming Malaysia’s leading tourist destinations.The company's gaming business, which operates its casinos both locally and internationally, has also posted strong results in recent years. Strong performance from the leisure and hospitality division has improved overall revenue and profit growth for Genting. †¢Strong performance of oil and gas Revenues for the oil and gas division of Genting have consistently improved in recent years. Although the division contrib uted just 2% to Genting’s revenues in fiscal year 2006, it recorded revenues of MYR141. 3 million (approximately $40. 1 million), a 19. % increase over the previous year. From 2002-2006, the oil and gas division grew at a CAGR of 29%. The phenomenal success of the division is attributed to significantly higher oil prices and increased production. Genting expects an even stronger growth for the oil and gas division in the future from increased oil production in Muturi (Indonesia) and China. WEAKNESS †¢Weak performance of property and manufacturing divisions Despite an increase of 7. 7% in fiscal year 2006, the property division's revenues have been volatile over the recent years.For the period 2003-2006, the division's CAGR was -6%, the lowest among all the company's business divisions. Despite a 6% increase in revenues, the manufacturing division's profit before tax declined 44% in fiscal 2006 over the previous year. Weak performance of these divisions would affect the o verall growth of the company. †¢Weak returns Genting has recorded weak returns in the last few years. Its return on investments and return on equity for trailing twelve months (TTM) December 2006 were 10. 2% and 13. 5%, respectively, lower than the industry averages of 10. % and 16. 8% for the same period. Weak returns reflect the inability of the management to deploy assets in profitable avenues, and this could result in decreasing investor confidence. OPPORTUNITIES †¢Growing wealth of Asian population Strong economic growth is expected to improve the spending habits of leisure travellers in the Asian region. A number of Asian countries are expected to record a significant CAGR in GDP per capita in the next five years, including: China (10. 1%), India (8. 1%), Thailand (7%), Singapore and Malaysia(6. 6%).Consequently, disposable income in these countries is expected to grow in the next five years. India’s disposable income records the highest CAGR of 11. 1%, Thaila nd, 8. 4%, China, 8. 1%,Malaysia, 5. 5% and Singapore, 5. 3%. Genting's foreign visitors mostly come from these countries. As such, the company stands to profit from the improving economic conditions of these markets. Rising income levels will increase demand for leisure and hospitality services. †¢Government initiatives to promote Malaysia The importance of tourism to the Malaysian economy has grown considerably in recent years.The joint efforts of Malaysia’s Tourism Ministry and Malaysia Tourism Promotion Board (MTPB) to stimulate tourism activities are expected to result in higher tourist arrivals in Malaysia. The MTPB hosts trade, tourism and consumer fairs around the world to promote the country’s culture and tourist attractions. In fiscal year 2005, there were a total of about 15. 8 million international arrivals in Malaysia. Annual targets announced under the Ninth Malaysia Plan (2006-2010) include an increase in international arrivals from 17. 3 million in 2006 to 20 million by 2010.In addition, the Malaysian government recently announced a five-day work week for civil servants, which translate to a greater number of holidays available for Malaysians. Also, the presence of low-fare air travel will boost the leisure and tourism industry in Malaysia. This positive outlook of Malaysian tourism presents the company with growth opportunities. †¢Strong outlook for China’s energy sector Demand for worldwide energy is expected to report strong growth until 2025. Energy demand from China is expected to grow by an average of 3. 2% annually until 2025, to reach a volume of 14. 2million barrels per day (bbl/d).Genting has consistently expanded its oil and gas assets including the acquisition of four power plants in China. China is the world's second largest consumer of petroleum products and the company stands to benefit from the growth in China’s energy sector. †¢Rising demand for biodiesel The European Union has a targe t of replacing 5. 75% of diesel with renewable sources by 2010. In view of this growing European demand for bio fuels, the Malaysian government is encouraging the use of palm oil to the production of biodiesel. The country is also preparing to change from diesel to bio-fuels in the near future.It has stipulated that from 2007, all diesel sold in Malaysia must contain5% palm oil. The plantation division of Genting is involved mainly in oil palm plantations, palm oil milling and related activities. It could therefore take advantage of the new opportunity to improve its revenue growth. THREATS †¢Intense competition Genting's leisure and hospitality division is expected to face stiff competition from new leisure attractions in Asia. Disneyland Hong Kong, which opened in September 2005, has emerged as a key competitor The Disneyland attracted approximately 5. million visitors in its first year of operation and is expected to increase to about 10 million annually. Genting is also fac ing competition from casinos in Macau. Macau has at least fourteen casinos, of which the biggest is the Casino Lisboa. Four casino resorts are scheduled to be launched in the next few years in Macau. Disneyland Hong Kong and casinos in Macau could draw tourists away from Genting's leisure and hospitality locations, which would reduce revenue growth. †¢Natural disasters and epidemics The leisure and hospitality is vulnerable to natural disasters and epidemics.In 2003, the outbreak of Severe Acute Respiratory Syndrome (SARS) adversely affected the Star Cruises operation. Star Cruises was also badly affected by the tsunami in 2004. In 2005-2006, outbreak of bird flu affected the leisure and travel industry including cruises. Natural disasters and outbreak of epidemics such as SARS and bird flu in the future could reduce tourist traffic to resorts, casinos and cruise ships of Genting, which would pull revenue growth down. †¢Weakening demand for residential housing Demand for r esidential properties in Malaysia is weakening.Demand for housing in 2006 was lower than 2005. Moreover, the Malaysian GDP growth for 2007 is expected to be 5. 0% down from 5. 8%in 2006 which could have a corresponding effect on Malaysian housing. The company has a significant presence in residential housing. It has recently launched two residential properties: Asiatic Cheng Perdana and Asiatic Indahpura. Excess supply in the Malaysian residential property market and the consequent fall in property prices would negatively impact the performance of Genting's property division.

Infancy and Early Childhood Developement Essay

It is amazing that our earliest memory is still years after we first begin to develop. No one remembers being a one celled zygote or any aspect of the prenatal stage. And the first years, from birth to two, are for the most part a mystery as well. My earliest memory is playing on a porch at a trailer my parents were renting. It is only now that it is realized that my personality was most likely shaped in those early years. Before my memory was fully developed my likes and dislikes, attitude toward affection and sense of humor were all impacted by choices made by my parents. FAMILY EFFECT Perhaps the greatest influence in any person’s life is their family. If a child has at least one emotionally supportive parent then there self-esteem will likely be higher than a child with no one to support them emotionally. However, many things can affect a child well before they take their first breath. Prenatal care is a very important stage of development; it is during this stage that our bodies transform from one sperm combining with an egg to the very complex creatures that we become. How does family come into play with this stage? It is during this stage that soon to be parents can choose to terminate a pregnancy or not. So in a way, it is in the prenatal stage that our families can affect our lives the most. Once a zygote becomes an embryo and then becomes a fetus a baby is born. It is now when the family will begin to determine how well the baby’s emotional and social aspects develop. The family will influence the newborn baby emotionally and socially by how they interact with them. For example if a father is unsure how to hold, change, feed or dress a baby and distances himself from the baby it is possible and likely that the baby will be hesitant when the father does eventually come around. Likewise if parents are affectionate, caring and encourage learning in the first years then the child can become excited about learning and gain a higher level of self-esteem. PARENTING STYLES According to Diana Baumrind there are three types of parenting styles; there is the authoritarian parent, the permissive parent and the authoritative parent. The authoritarian parent is very demanding and does not tolerate failure to meet their high standards. When the child disobeys they can expect physical punishment (spanking not abuse). This method can be effective when used consistently, for example if a child is disobedient about cleaning their room but is only punished at random (spanking or grounding) then the room will likely remain messy and cluttered. Permissive or indulgent parents seek to be a friend to their children and would rather not take responsibility for the shaping of them. They are portrayed in popular culture by being inept and lazy when in reality it is possible that permissiveness results as a feeling of resentment from authoritarian parents. Regardless of the reason for the parent’s indulgent behavior they are likely to have low standards for their children and be lax when it comes to rules and punishment. The authoritative parents form a middle ground between the authoritarian and the permissive parents. Authoritative parents listen to their children’s feelings and concerns while maintaining a role of authority. When comparing Baumrind’s parenting types it seems that a different type would be most useful to each stage of development. For the early childhood stage (birth to two years) the permissive parent may have the most affect being that they are able to hide frustration and disappointment. Also having strict rules and high expectations, as with the authoritarian, could lead to fear and anxiety in the child. EARLY CHILDHOOD EDUCATION There are two major options for parents when selecting a preschool or day care program for their child. Parents can choose from child-centered programs or teacher-directed programs. Child centered programs allow children more freedom to choose their own activities and are generally less structured believing that children will benefit from being able to express themselves through art, dress up, music and dance. Teacher directed programs are more similar to grade school in that children will be expected to follow along with the teacher’s lesson plan and utilize listening skills during instruction. These programs will typically follow a schedule for all the children to complete activities at scheduled times. Through personal reflection you can imagine that if you were at a teacher-directed program and now as an adult enjoy structure that may be one of the more significant reasons. Conversely attending a child-centered preschool can influence a child to become more musically inclined and develop a greater appreciation for the arts. Of course there is also another option for parents, and that is to keep the child at home until they begin kindergarten. This was the social norm until the 1990’s and is still practiced by some families where one parent is home full time. CONCLUSION Desmond Tutu said, â€Å"You don’t choose your family. They are God’s gift to you, as you are to them. † To me, this means that parents should understand the extreme importance of their role in their child’s life. Especially in the early childhood stage as this is a vital time for children to develop emotionally, physically and socially. When parents accept the challenge of being an active participant in the development of their children they are giving their children the opportunity to grow and prosper in a way that may not have been possible for them. REFERENCES Berger, K. S. (2001). Prenatal Development and Birth. The Developing Person through the Life Span (5th ed. , pp. 88-119). New York: Worth Publishers. Berger, K. S. (2001). Early Childhood: Psychosocial Development. The Developing Person through the Life Span (5th ed. , pp. 264-291). New York: Worth Publishers. Berger, K. S. (2001). Early Childhood: Cognitive Development. The Developing Person through the Life Span (5th ed. , pp. 236-263). New York: Worth Publishers. Cherry, K. (n. d. ). Early Childhood Development – What Is Early Childhood Development. Psychology – Complete Guide to Psychology for Students, Educators & Enthusiasts. Retrieved December 18, 2012, from http://psychology. about. com/od/developmentalpsychology/ss/early-childhood-development. htm Family Quotes Page 2 – BrainyQuote. (n. d. ). Famous Quotes at BrainyQuote. Retrieved December 18, 2012, from http://www. brainyquote. com/quotes/keywo.

Terrorism Waves In America Research Paper Example | Topics and Well Written Essays - 3750 words

Terrorism Waves In America - Research Paper Example This study is structured around the hypothesis that terrorism in the US lacks particular/substantive definition due to evolutionary forces experienced under different waves. The definition of terrorism is therefore multifaceted according to the various waves experienced. Terror is a deep-rooted phenomenon in the modern world. Though having begun in the late nineteenth century in Russia, the modern terror has evolved to cover the whole world, with the US such a hard hit victim. The simplest definition of a wave is an activity cycle per a given period characterized by phases of contractions as well as expansions. According to the report, each wave as described had a particular predominant defining feature, which also would explain the naming. This paper makes a conclusion that , terrorism is the use of force unlawfully against a person or property with a motive of intimidating and or coercing a sovereign government, the population of civilians or such a segment guided by an objective of political as well as social gain. This definition serves as the basis of the paper with the understanding that it is not wholly universally accepted but that it has common features that are ascribed to terror activities in general. Terrorism activities in the United States have nevertheless been very dynamic and this explains the evolution of the definitions accorded to terrorism in the states. The terrorism waves are ‘anarchist wave,’ ‘anti colonial wave,’ ‘new left wave’ as well as ‘religious wave’.

Causes and Effects of the U.S. Unemployment Research Paper

Causes and Effects of the U.S. Unemployment - Research Paper Example Simply put, it is the lack of a job. Let’s consider different types of unemployment prevailing in the United States. Frictional unemployment is one of the most common forms in any job market whereby transitions in the job market make people jobless only temporarily. For instance, a person who has not started his/her new job after resigning from his previous job is experiencing frictional unemployment. Another form is the structural unemployment in which case the job market usually does not have enough capacity to absorb qualified people in a given field who have undergone training. For instance, the emergence of the web-based economy saw the enrolment of many people for the course across the United States, making it hard for them to find jobs in the field upon graduation, since there was already a surplus of qualified people in the field (Milan 37). This type is also common in economies experiencing slow or negative growth rates in certain fields. Cyclical unemployment refers to the changes in employment patterns that relate to the cyclical changes in a given economy characterised by highs and ups. Recessions and economic booms are the factors upon which this type is defined. During the recession periods, the market is not capable of providing employment for many employees in a given sector, hence, making them be unemployed until the economy rebounds. There is the newly introduced type known as technological unemployment in which the introduction of new automated and computerised systems lead to layoffs and lack of job openings in previously employing industries of firms. The last category is the seasonal employment, which refers to a situation whereby rates of unemployment vary according to the yearly seasons, with some having many job opportunities while others hardly having any. Another example of this type is represented by the tourism sectors in many countries where the frequency of tourists changes with seasons, with drier seasons having high rates of employment while the winter leads in unemployment rates (Markus 87). Causes of unemployment There are many reasons the economic and social development experts, as well as politicians, point to as the causes of unemployment in the United States of America. The first is the country’s population, which is projected to be a factor on an upward trend. Analysts say it has led to a higher ratio of unemployment among the citizens. The argument is that jobs have remained relatively the same due to mechanization and computerization of many production systems while the population rises. There is severe competition on indigenous companies from foreign companies, which have cheap labour in their home countries hence being able to produce cheaply and consequently leading to lower pricing of goods. This has resulted in the closure of several companies across the country with the obvious effect of leaving their employees jobless. Many companies are embracing the practice of flattening th eir structures to facilitate smooth operation of business, in contrast to the tall company structures. Others have introduced software that can carry out several tasks at once, taking the place of several persons at once. Outsourcing of cheap labour from other parts of the world is also a common occurrence among

Maritime Logistics Essay Example | Topics and Well Written Essays - 2000 words

Maritime Logistics - Essay Example The second chapter deals exclusively on the group’s supply chain by analysing the process and practices with key supply chain issues that affect the top and bottom line of the company. It also discusses about the drivers that maintain the group’s competitiveness in three key dimensions such as – quality, cost and time. The subsequent chapter explains about the realm of maritime logistics delving deep into how the maritime process can be seamlessly integrated into the logistic and supply chain system of a business. At the end it discusses how the group can leverage on maritime logistics and minimise certain endemic supply-chain issues such as the bullwhip effect. The ArcelorMittal, the world’s number one steel company with over 32000 employeesi and presence in over 60 countries and is a truly global steel maker. It is a market leader in all the global steel markets such as automotive, construction, household appliances and packaging. The group holds sizable captive supplies of raw materials and operates a huge distribution network throughout the globeii. With revenue of $124.9 billion and crude steel production of 103.3 million tonnes, it represents almost 10 percent of the global steel outputiii. ArcelorMittal’s chief operations include providing ‘steel solutions and services’. The group operates in more than 500 centres and 32 countries, providing to approximately 200,000 customers a full portfolio of flat and long products, tubes and stainless steel; adding value through further processing and providing technical, engineering and consultancy supportiv. A detailed list of products is placed at the appendix to this reportv. The group through its integrated business model operates in the entire hierarchy of the business from mining and sourcing of raw materials to managing a mammoth mobilisation network that transports the raw materials to the factory location, followed by designing and manufacturing

Reading and Answer the Question Essay Example | Topics and Well Written Essays - 500 words

Reading and Answer the Question - Essay Example It is quite difficult for quite a number of people to identify artistic works. For instance, the article, â€Å"living with art† the author indicates that visitors into the Vietnam Veterans Memorial are initially unaware of small details about the artistic nature of the memorial, like the â€Å"†¦low wall at their feet† (Gracyk, 118). Through the inability of recognizing small details, there is a possibility of insinuating that they are not in a position to explore the characteristics of some pieces of art. My perception about art differs from the majority since I take recognition of the fact that art is essentially part of the human nature, and for this reason, exploring some of the detailed characteristics of artistic pieces. Through this, there is a possibility of having a better understanding of the natural world. The author uses the term â€Å"outsider art† to describe the creativity of artists that are self-taught, which are pieces that originate from people that are aware of their physical world (Hofstadter and Kuhns, 39). According to experiences by Maya Lin, her artistic ability emanated from her desire to make people aware of the natural world. These types of art have a common expression of the classical art history, which develop a unique artistic culture among a number of people. It is possible to see pure creativity to the human impulses that are manifested in people without crippling some of the effects of formal training. There is a possibility that the artistic world is a reflection of the natural world. Through this provision, one might argue that appreciation of art emanates from the aesthetic appeal that it provides. However, the entire purpose of art should not necessarily be beautiful since works of art depends on the message that the artist is seeking to instill to the viewers. On the other hand, the consideration of

How East-Asian Martial Films Have Influenced Hollywood Cinema Literature review

How East-Asian Martial Films Have Influenced Hollywood Cinema - Literature review Example This genre has been known to incorporate richly detailed choreographed action scenes with high-flying kicks and martial art techniques. When it was first seen in Asia, it was far-removed from the American film genre and style. However, it soon became a common feature in the Hong Kong film industry (Michallet-Romero, 2003). While trying to preserve the traditional stories of Chinese heroes, Hong Kong film directors translated martial arts techniques into film and in the process influenced the Hollywood film industry. The Wuxia tales in Chinese history were representations of male and female sword masters who represented much heroism in their actions (Garnet, 1999). These tales of heroism were developed in an era dominated by Confucianism and the teachings of this religion. Confucius was very much focused on loyalty, obedience, and on fulfilling one’s duty to one’s family. The father was considered the head of the household and as such total respect was owed him by the re st of the family (Morgan, 2001). Confucius also advocated the belief that those who were stronger must protect the weak, the aged, and those who were unable to defend themselves. Confucius also supported the ideal leader, ordering his warriors to live their lives with dignity and with valour. From these teachings grew wuxia literature. This literature was also enriched by the stories of the Buddhist religious leader Siddartha Gautama (Michallet-Romero, 2003). Buddha’s teachings incorporated philosophical beliefs to the wuxia tales and also advocated the idea of alleviating the sufferings of man. Physical disciplines were later associated with Buddhism and Confucianism and these movements were meant to enhance a person’s chi, which is considered to be the life force of all beings (Michallet-Romero, 2003). ... iplines were later associated with Buddhism and Confucianism and these movements were meant to enhance a person’s chi, which is considered to be the life force of all beings (Michallet-Romero, 2003). From these movements Kung Fu would soon evolve. The Wuxia tales presented the image of the hero – either male or female – as one who is able to wield a sword skilfully, travelling to distant lands and carrying out heroic deeds in defence of the powerless and the weak. These heroes were often known to travel alone, exemplifying their strong skills in martial arts and sword play (Desser, 2002). The relationship of master and student within these stories were also apparent. The wuxia tales also presented the virtues of justice, valour, and sacrifice for the greater good of the people. The protagonists were also usually of common lineage and with skill and training gained much prestige (Birrell, 1999). This protagonist was very much different from the protagonists portra yed in Western stories where the heroes were often of noble blood. Wuxia folklore eventually made its way into the common and the noble people of China and these stories were retold with slight changes in their characterizations, making them darker and flawed and somehow representing a danger to those who were weak. Due to these changes in their characterization, the heroes were often made to confront their dark side as well (Birrell, 1999). Eventually however, this wuxian hero would be able to redeem himself by favouring the original teachings of Buddhism and Confucianism, harnessing enough chi to make the ultimate sacrifice for the people. These wuxia tales became popular forms of literature in China and they became common themes among travelling groups of actors in China. When the Peking Opera was

RECRUITMENT & SELECTION ( Human Resource Managment) Essay

RECRUITMENT & SELECTION ( Human Resource Managment) - Essay Example (1). In my opinion it is in the traditional approach that the company demonstrates obligation to its own well-being and the well-being of its employees. The Obligation and Benefits of Internal Selection The case presented makes it very clear that the internal candidate has remained a loyal employee to the organization. The organization has an obligation to its own well-being and the well-being of its employees to recognize loyalty and maintain the loyalty of its employees. (2). Denying this obligation to a talented internal candidate will make employees reconsider their loyalty to the organization to the disadvantage of the organization. Let us look at morale among the employees of the organization in case of external selection. The lack of recognition of performance and loyalty and the possible block to career advancement will lower their morale and act as a de-motivating factor, influencing their performance. (1). Minimizing costs in its business activities is an obligation of an o rganization. By opting for the suitable internal candidate the costs involved in easing the new entrant into the job position and organization are removed.

Effect of luxury cars on the uk market Essay Example | Topics and Well Written Essays - 2000 words

Effect of luxury cars on the uk market - Essay Example In other markets, especially those in the South Eastern Asia region make significant sales of other types of luxury cars too (TATT, 2010). However, these markets are always limited to the sum total volume of sales by the overall size either of the industry or by the local conditions of the market and other preferences (Shende, 2014). Consequently, the market for luxury cars generally is presently undertaking some sort of social change with some of the luxury car brands seeming to be less remote. The brands are also seen to be less varied and at the same time less exclusive with the quality, that they have in improving lives (TATT, 2010). As a result, the increment in the competition between different car makes has intensified the relevance of brand identity (Shende, 2014). As the standards of the product continue to go up, the customer’s perceived image of the car brand plays a major role in making the buying decision. Some of the luxury cars such as the BMW, Lexus and the Mercedes- Benz are bound to develop some values and characteristics that are seen to reflect the ever-changing social values (TATT, 2010). The values then influence the buyer’s emotions, so that the brands maintain their positions in various world regions of the global market (Shende, 2014). In the past several years, the research into the customers’ perception and their behaviors in the luxury car industry has been driven by a couple of researchers all over the world (Shende, 2014). There is very little literature both in writing and in softcopy means that document any research done concerning customer perception of luxury cars. Most of the work is focused on the loyalty of the consumers and that of brand switching (ANURIT, NEWMAN & CHANSARKAR, n.d.). The key research that has been made has focused on the low priced segment ranges of cars rather than the luxury car segment in which any choices between the choice of individual potential buyers and brand image concept play a big

Website Review Assignment Essay Example for Free

Website Review Assignment Essay The website www. ancientgreece. com is an interactive web location that serves as a reference point for the history and philosophy behind Greek contributions in the various art forms used in the rituals of basic everyday living to sacred cultural convention. The homepage incorporates quotes from famous scholars, such as, Aristotle and Archimedes, and a menu of thumbnail pictures that link to indepth summaries, examples, and pictures of Greek art, architecture, history, the Olympic Games, wars, geography, mythology, people, culture, and society. The Forum is a message board to share and discuss Greek related scholastic topics and issues, and to meet and talk to other students and professors. The Essays section allows the user to browse ancient Greek essays in the topics listed above. It is also possible for anyone to upload an essay to discuss it with the other users. Help Build the Foundations is the place to contribute shared knowledge, photos, and comments on articles or essays, discuss topics, or submit essays. The photo gallery holds pictures and information on famous artifacts, marble sculptures, and paintings. The course directory can be utilized to put people in touch with universities that offer Ancient Greek studies. The website also offers a glossary, and a bookstore with DVDs, posters, and books for purchase. For full access to the site you must register. Ancient Greece is considered the center of art and intellect. Religion dominated Greek life and that is exposed through their art and architecture. Statues were used to enlighten the communities about the stories about the Gods. Many statues that have survived are actually Roman copies of the originals. The Olympic Games were created and held to honor the Gods, complete with animal sacrifices. Theater was a main source of entertainment. Tragedies and comedies revolved around politics and the Gods. Some of the most influential playwrights, philosophers, historians, epic poets, mathematicians, and sculptors came out of ancient Greece. This website is a complex site with extensive information about Greece and their achievements and contributions, stretching from the Neolithic Age to the Classical Period. In terms of art, this website has pictures of artifacts, sculptors, mosaics, and paintings, but never mentions music. Music was an integral part of ancient Greek life and tradition. This site needs to include a section summarizing the variety of music the Greeks listened to, famous musicians, pictures and facts about instruments, and the purposes music served in daily ritual and cultural tradition.

The recession & economy Essay Example for Free

The recession economy Essay In order to understand the recession that the economy is going through, it is important for us to take note of the meaning of debts in the corporate world. We can look at the stock market as a big debt market where people buying stocks are in effect â€Å"loaning† money to companies for them to use. Of course, the rate of return of these loans is different from the typical kind as the stock buyer can gain or lose significantly based on the company’s future capacity to pay. Therefore it is intuitive to say that if buyers fear that they would not gain from buying stocks, they would have no reason to do so. As Cook reports, this is precisely the situation where the United States Economy is in at the moment. Government and corporate spending has reached an alarming rate investors no longer believe that their debts can be repaid (Cook). Furthermore, Cook explains that the boom of the market in China and the perpetual pull of Middle Eastern oil magnates have added to the U. S. economic strain. When put together, these are what make the components of the current economic recession. To solve such a vast problem, it is important to go to the source: money. Giving tax cuts would not solve the problem simply because even if interests are down, the public doesn’t have faith in the economy enough to invest. In fact, the Federal Reserve has just recently tried this and it proved to be a very temporary solution. Government spending is just way too high and we are not getting any returns from places where we are spending money the most, Iraq. Unfortunately from an investor’s point of view, backing out of Iraq seems to be a losing bargain. According to Gordon (27), we have simply invested too much into it to get nothing in return. My solution would be to step up operations in extinguishing all rebel forces. As soon as this is done, we can start forging economic alliances that could tie the Iraqi oil reserves to our economy. Oil-rich middle and southern Iraq could greatly increase our economic position and jolt the market back to life. I believe that this is the best way to solve the problem. Works Cited Gordon, Thomas. The Economics of the Iraq Post-War Occupation. Rudyard Books, N. Y: 2006 Cook, Robert. It’s Official: The Crash of the U. S. Economy has begun. Global Research Jun 14, 2007, Jan 25 2008 http://www. globalresearch. ca/index. php? context=vaaid=5964

A review of Bioactivation and Tissue Toxicity

A review of Bioactivation and Tissue Toxicity Kong Wei En (BP0711031415) Raymond Koh Chee How (BP0711031287) Jennie Lee Sheah Lin (BP0711031372) Prashanthini A/P Janardanan (BP0711031156) Hong Wei Siong (BP0711031194) Shalini A/P Shanmugavelu (BP0711031145) Introduction Xenobiotics are foreign chemicals in the body [1]. The human body has adapted processes collectively termed as biotransformation to excrete these xenobiotics [1,2]. Biotransformation generally occurs sequentially in two phases [1,2]. Phase I reactions add new functional groups to the parent compound while phase II reactions conjugate these new functional groups with polar groups [1,2]. The end-result of biotransformation is decreased lipid solubility, thus increasing renal excretion [1,2]. The liver is the chief site for biotransformation, [1,2]. Enzymes such as cytochrome P450 and peroxidase enzymes are responsible for biotransformation [3,4]. Occasionally, bioactivation occurs, in which the inert parent compound is modified into toxic metabolites [1,3,4]. The toxic metabolites are either electrophiles or free radicals, which interact with body tissues, subsequently causing toxicity [3,5]. Electrophiles Electrophiles are species deficient in electron pair generated through Phase 1 metabolism by CYP450 [5]. They are short-lived (with the possible exception of some acyl glucuronides) and not usually detectable in circulation [5]. Electrophiles can be generated from carbon, nitrogen or sulphur containing compounds [4]. The most frequently metabolised structural alerts are aromatic systems with electron-donating substituents and some five-membered heterocyclic [6]. Electrophiles cause toxicity through the formation of irreversible covalent bond to nucleophilic tissue components which includes macromolecules (proteins, nucleic acids and lipids) or low molecular weight cellular constituents [4]. Covalent binding generates potent and long lasting toxic effects because the covalently modified enzyme/receptor is permanently inactivated [4]. The covalent binding to DNA leads to mutation, tissue necrosis, carcinogenicity and tumour formation [4]. Mutations arise when the electrophiles escape the repair mechanisms of the cell, may be fixed and passed to the progeny [4]. If the electrophiles bind to protein, they will disturb the physiological homeostasis, leading to cell death [7]. Examples of electrophiles include epoxide, hydroxylamines and aldehydes [4,5]. Free radicals Free radicals (species containing an odd number of electrons) may be cations, anions or neutral radicals [8]. Free radicals are generally formed via NADPH CYP450 reductase or other flavin containing reductases [8]. They provide toxicity by peroxidation of cellular components. An important class of free radicals is organic free radicals such as hydrogen peroxide and superoxide anion [8]. The potential toxicity of free radicals is far greater than electrophiles [8]. Free radicals are able to produce chemical modifications and damage to proteins, lipids, carbohydrates and nucleotides [9]. If the reactive free radical is formed close to DNA then it may produce a change in the structure resulting in a mutation or cytotoxicity [9]. Protein and non-protein thiol groups are readily oxidized by many free radicals and may lead to profound changes in enzyme activity [9]. Another major pathway of metabolic disturbances is depending on covalent binding with cell components such as protein, lipid and nucleic acid to from a stable covalently bound adduct that may grossly distort structure and function [9]. Reactive free radical may also damage cells through membrane damage [9]. Examples of free radicals include hydrogen peroxide, hydroxyl radical and peroxynitrite [10]. Examples of drugs undergoing bioactivation and causing subsequent tissue toxicity Table 1: Several drugs, with their corresponding toxic metabolic pathways and the subsequent adverse effects. Drug Metabolic pathway Adverse effects Chloramphenicol Chloramphenicol is first oxidised by CYP monooxygenase into its dichloromethyl moiety [11]. Hydrochloric acid is then eliminated to produce a reactive metabolite that interacts with the Æ -amino acid of a lysine residue in CYP monooxygenase [11]. The enzymatic reaction is eventually retards over time, leading to adverse effects [11]. Apalstic anemia [12] Bone marrow toxicity [12] Acetaminophen The reactive metabolite is called N-acetyl-p-benzoquinone imine (NAPQI) [11]. Metabolic pathway 1: Acetaminophen undergoes N-oxidation to become N-hydroxyacetaminophen, which then undergoes dehydration to form NAPQI [11]. This pathway is probably uncommon as N-hydroxyacetaminophen is not a chief intermediate in the oxidation of acetaminophen [11]. Metabolic pathway 2: NAPQI undergoes a Michael-type addition with either glutathione or protein thiol groups [11]. Hepatotoxicity [11,12]. Tienilic acid Tienilic acid is oxidised by CYP2C9 to either thiophene sulfoxide or thiophene epoxide [11]. These electrophilic reactive intermediates alkylate CYP2C9, permanently binding themselves to the enzyme [11]. The enzyme is subsequently inactivated [11]. The body then produces anti-LKM2 autoantibodies against the native CYP2C9 enzyme and the modified CYP2C9 enzyme [11]. Immunoallergic hepatitis [11] Halothane Matabolic pathway 1: In hypoxic states, halothane undergoes reduction to produce the 1-chloro-2,2,2-trifluoroethyl free radical [11]. This free radical performs a radical attack, leading to the necrosis of hepatocytes [11]. The radical may also react with the Fe2+ in the CYP enzyme to form an iron ÏÆ'-alkyl complex [11]. This complex then causes the necrosis of the hepatocytes [11]. Metabolic pathway 2: Halothane undergoes oxidation to produce trifluoroacetyl chloride [11]. Liver proteins are then trifluoroacetylated on their Æ -NH2-lysyl residue [11]. This newly formed neoantigen evokes an immune response towards the liver [11]. Severe hepatitis [11] Valproic acid Valproic acid is metabolised by CYP2C9 into 2-propyl-4-pentenoic acid, also termed as Δ4VPA [11]. This metabolite can then undergo two pathways [11]. Metabolic pathway 1: CYP enzymes metabolize Δ4VPA into a reactive metabolite, which then proceeds to alkylate the prosthetic heme of the CYP enzymes [11]. Hence, the enzymes are inhibited [11]. Metabolic pathway 2: The Δ4VPA metabolite undergoes ÃŽ ²-oxidation to generate the Coenzyme A ester of 3-oxo-2-propyl-4-pentenoic acid [11]. This new metabolite alkylates the terminal enzyme of ÃŽ ²-oxidation (3-ketoacyl-CoA thiolase) by a nucleophilic attack at the olefinic terminus [11]. Hepatotoxicity [11] Troglitazone Metabolic pathway 1: The thiazolidinedione ring undergoes oxidative cleavage to produce a reactive sulfoxide intermediate, which spontaneously opens its ring [11]. Metabolic pathway 2: The phenolic hydroxyl group of troglitazone undergoes a one-electron oxidation catalysed by CYP3A to produce an unstable hemiacetal, which spontaneously opens to form a quinine metabolite [11]. The quinine metabolite then undergoes the metabolic pathway described earlier (metabolic pathway 1) [11]. Metabolic pathway 3: The unstable hemiacetal produced in metabolic pathway 2 may undego hydrogen abstraction, resulting in the production of an o-quinone methide derivative [11]. Hepatic failure Death (due to hepatic failure) [11]. Part 2: Applications of Bioactivation and Tissue Toxicity in Abacavir and Lidocaine Abacavir Abacavir (ABC) is an anti-HIV drug classified as a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) [13]. ABC possesses a significant role in the treatment of HIV patients [13]. First, ABC is subjected to phase I oxidation to produce ABC-carboxylate, followed by phase II glucuronidation to generate the inactive glucuronide metabolite [13]. Both the glucuronide and carboxylate metabolites are chiefly eliminated in the urine [13]. ABC undergoes bioactivation to form reactive aldehyde metabolites [13]. ABC metabolism to ABC-carboxylate involves a two-step oxidation via an aldehyde intermediate (unconjugated ABC-aldehyde) which rapidly tautomerizes to the more stable conjugated ABC-aldehyde [13]. This reactive metabolite is capable of reacting with proteins to produce covalent adducts, which results in the occurrence of adverse effects [13]. The most prevalent acute ABC-induced adverse effects are the potentially life-threatening hypersensitivity reactions (HSR) that occur within the first 6 weeks of treatment [13]. ABC also possesses the potential to induce cardiotoxicity, which raised further concerns about the prolonged administration of this drug [13]. Lidocaine Lidocaine has been extensively used in the treatment of ventricular arrhythmias [14]. It is also usually administered intravenously to treat and prevent cardiac arrhythmias after acute myocardial infarction [14]. Its chemical structure is an amide with an aromatic group [15]. Lidocaine is chiefly metabolized by the microsomal enzyme system in the liver [15]. The major biotransformation pathways are oxidation and hydroxylation [14]. Lidocaine undergoes oxidative N-deethylation to form the toxic mono-ethylglycinexylidide, which is then hydrolysed to 2,6-xylidine [14,15]. Finally, 2,6-xylidine is modified to 4-hydroxy-2,6-xylidine, which is excreted in urine [14]. Lidocaine also undergoes hydroxylation of the aromatic nitrogen to form N-hydroxylidocaine and the toxic N-hydroxymonoethylglycinexylidide [14]. The active and toxic metabolites known as mono-ethylglycinexylidide and N-hydroxymonoethylglycinexylidide primarily cause neural and cardiac toxicity [14,15]. Early signs of CNS intoxication include shivering, muscular twitching and tremors of the facial muscles [15]. As toxicity is low, it is safely and extensively used to treat arrhythmias [15]. Conclusion To eliminate xenobiotics from our body, processes collectively termed as biotransformation occurs in two phases. However, toxic metabolites (electrophiles or free radicals) may be produced in processes called bioactivation, which interact with body tissues and cause tissue toxicity. The bioactivation and subsequent adverse effects of abacavir and lidocaine has been discussed in detail. References [1] Rang H, Dale M, Ritter J. Rang Dales pharmacology. 7th Edition. Edinburgh: Churchill Livingstone; 2011. [2] Dekant W. The role of biotransformation and bioactivation in toxicity. Springer. 2009; 57-86. [3] Walsh J, Miwa G. Bioactivation of drugs: risk and drug design. Annual review of pharmacology and toxicology. 2011; 51: 145-67. [4] Brahmankar DM, Jaiswal SB. Biopharmaceutics and Pharmacokinetics A Treatise. 2nd Edition. Vallabh Publications Prakashan; 2012. [5] Boyer T, Manns M, Sanyal A, Zakim D. Zakim and Boyers hepatology. Philadelphia, PA: Saunders/Elsevier; 2012. [6] Walsh J, Miwa G. Bioactivation of drugs: risk and drug design. Annual review of pharmacology and toxicology. 2011; 51: 145-67. [7] Ioannides C, Lewis DFV. Cytochromes P450 in the Bioactivation of Chemicals,Current Topics in Medicinal Chemistry. 2004; 4:1767-88. [8] Leon Shargel , Andrew Yu, Suzanna Wu-Pong. Applied Biopharmaceutics Pharmacokinetics. 6th ed. USA :McGraw Hill ; 2012. [9] Trevor F. Slater. Free-radical mechanisms in tissue injury. Biochem J. 1984 Aug 15;222(1):1-15. [10] V. Lobo, A. Patil, A. Phatak, N. Chandra. Free radicals and functional foods : impact on human health. Pharmacogn Rev. 2010 Dec; 4(8): 118-26 [11] Wermuth CG, editor. The Practice of Medicinal Chemistry. 3rd edition. UK and USA: Elsevier Ltd.; 2008. [12] Nassar AF, Hollenberg PF, Scatina J, editors. Drug Metabolism Handbook: Concepts and Applications. New Jersey and Canada: John Wiley Sons, Inc.; 2009. [13] Griloa NM, Charneirab C, Pereiraa SA, et al. Bioactivation to an aldehyde metabolite-Possible role in the onset of toxicity induced by the anti-HIV drug abacavir. Toxicology Letters. 2014; 224: 416-23. [14] Collinsworth KA, Kalman SM, Harrison DC. The Clinical Pharmacology of Lidocaine as an Antiarrhythmic Drug. Circulation. 1974;50:1217-30. [15] Johansen Ø. Comparison of Articaine and Lidocaine used as Dental Local Anesthetics. Faculty of Dentistry, University of Oslo; 2004. 25 p.

The Power of a Woman :: essays research papers fc

The Power of a Woman The familiar saying "Behind every great man is an even greater woman" can certainly hold true in many cases. A woman may very well be the driving force behind any successful man. However, a woman can also use her strong influence in a negative way. This can be seen in Macbeth, where Lady Macbeth is the evil force behind Macbeth's cruelty and evil doings. In Shakespeare's Macbeth, Lady Macbeth is the main reason that Macbeth is transformed from a noble, respected Thane into a ruthless, murderous character. Lady Macbeth fuels his inner desire for power and brings forth his greed and ambition, which both eventually lead to his downfall. The tactics that Lady Macbeth use to drive her husband to this downfall are manipulation, dominance, and her evil nature. Lady Macbeth manipulates Macbeth into believing that he is a coward and a bad husband, which persuades him to agree to the murder of King Duncan. She dwells on the fact that he is a coward, when she says "My hands are of your colour, but I shame/ to wear a heart so white" (2.2.64-65). This instills feelings of embarrassment into his mind, and manipulates him into believing that if he does not murder King Duncan, he will be a weak, cowardly man. Not only is she challenging his manhood, by appearing to be the stronger and braver of the two, but also, by calling his heart "white", she is criticizing his cowardice. The fact that his wife is undermining his masculinity causes Macbeth to want to be stronger, and not to appear weak and timid. When Lady Macbeth yells "Infirm of purpose! Give me the daggers. The sleeping and the dead/ are but as pictures. 'Tis the eye of childhood/ that fears a painted devil" (2.2.53-55), she further contributes to the shame which she has driven into Macbeth's mind. She bluntly tells him that he is acting like a weak, nervous child, and insults him for being afraid of something that is already dead! This shame encourages Macbeth to want to consent to his wife's plan. Another method which Lady Macbeth uses to manipulate her husband's mind is by making him feel guilty for being a bad husband, who breaks his promises: "What beast was't then/ that made you break this enterprise to me?" (1.7.47-48). She knows that by saying this, he will feel remorse for breaking a promise to his wife whom he loves so much. The Power of a Woman :: essays research papers fc The Power of a Woman The familiar saying "Behind every great man is an even greater woman" can certainly hold true in many cases. A woman may very well be the driving force behind any successful man. However, a woman can also use her strong influence in a negative way. This can be seen in Macbeth, where Lady Macbeth is the evil force behind Macbeth's cruelty and evil doings. In Shakespeare's Macbeth, Lady Macbeth is the main reason that Macbeth is transformed from a noble, respected Thane into a ruthless, murderous character. Lady Macbeth fuels his inner desire for power and brings forth his greed and ambition, which both eventually lead to his downfall. The tactics that Lady Macbeth use to drive her husband to this downfall are manipulation, dominance, and her evil nature. Lady Macbeth manipulates Macbeth into believing that he is a coward and a bad husband, which persuades him to agree to the murder of King Duncan. She dwells on the fact that he is a coward, when she says "My hands are of your colour, but I shame/ to wear a heart so white" (2.2.64-65). This instills feelings of embarrassment into his mind, and manipulates him into believing that if he does not murder King Duncan, he will be a weak, cowardly man. Not only is she challenging his manhood, by appearing to be the stronger and braver of the two, but also, by calling his heart "white", she is criticizing his cowardice. The fact that his wife is undermining his masculinity causes Macbeth to want to be stronger, and not to appear weak and timid. When Lady Macbeth yells "Infirm of purpose! Give me the daggers. The sleeping and the dead/ are but as pictures. 'Tis the eye of childhood/ that fears a painted devil" (2.2.53-55), she further contributes to the shame which she has driven into Macbeth's mind. She bluntly tells him that he is acting like a weak, nervous child, and insults him for being afraid of something that is already dead! This shame encourages Macbeth to want to consent to his wife's plan. Another method which Lady Macbeth uses to manipulate her husband's mind is by making him feel guilty for being a bad husband, who breaks his promises: "What beast was't then/ that made you break this enterprise to me?" (1.7.47-48). She knows that by saying this, he will feel remorse for breaking a promise to his wife whom he loves so much.

Jeffersonian Democratic Republicans :: History

  Ã‚  Ã‚  Ã‚  Ã‚  The Jeffersonian Democratic Republicans were characterized as strict constructionists. Which explains why they wanted the United States to be controlled by the states, not a central government.   Ã‚  Ã‚  Ã‚  Ã‚  On August thirteenth eighteen hundred, Thomas Jefferson addressed the nation to let individual know that The United States was much too large to have a central government to direct the affairs of the nation. Meaning that we have the need of state officials and not just the national leaders. Therefore, we have independent states to handle the events and laws within the boundaries of each state. Although at the international level we are as one United Nation.   Ã‚  Ã‚  Ã‚  Ã‚  On January twenty-third eighteen o eight, Jefferson informed Samuel Miller, who was a Presbyterian minister that the United States government could not interfere with a citizen’s religious beliefs. According to what was written in the first Amendment of the Bill of Rights â€Å" Congress shall make no law respecting an establishment of religion.† This became effective on December fifteenth seventeen ninety-one. There was nothing that can make one participate in religious exercises.   Ã‚  Ã‚  Ã‚  Ã‚  The cartoon illustrates the embargo of eighteen o eight and was confusing to the citizens. Because it was stated as the â€Å"Ograbme†   Ã‚  Ã‚  Ã‚  Ã‚  On December ninth eighteen fourteen, Daniel Webster a federalist from New Hampshire, gave a speech to the House of Representatives. His speech addressed the draft. Webster argued that it was not right to â€Å"take children away from their parents, and parents from their children. Jeffersonian Democratic Republicans :: History   Ã‚  Ã‚  Ã‚  Ã‚  The Jeffersonian Democratic Republicans were characterized as strict constructionists. Which explains why they wanted the United States to be controlled by the states, not a central government.   Ã‚  Ã‚  Ã‚  Ã‚  On August thirteenth eighteen hundred, Thomas Jefferson addressed the nation to let individual know that The United States was much too large to have a central government to direct the affairs of the nation. Meaning that we have the need of state officials and not just the national leaders. Therefore, we have independent states to handle the events and laws within the boundaries of each state. Although at the international level we are as one United Nation.   Ã‚  Ã‚  Ã‚  Ã‚  On January twenty-third eighteen o eight, Jefferson informed Samuel Miller, who was a Presbyterian minister that the United States government could not interfere with a citizen’s religious beliefs. According to what was written in the first Amendment of the Bill of Rights â€Å" Congress shall make no law respecting an establishment of religion.† This became effective on December fifteenth seventeen ninety-one. There was nothing that can make one participate in religious exercises.   Ã‚  Ã‚  Ã‚  Ã‚  The cartoon illustrates the embargo of eighteen o eight and was confusing to the citizens. Because it was stated as the â€Å"Ograbme†   Ã‚  Ã‚  Ã‚  Ã‚  On December ninth eighteen fourteen, Daniel Webster a federalist from New Hampshire, gave a speech to the House of Representatives. His speech addressed the draft. Webster argued that it was not right to â€Å"take children away from their parents, and parents from their children.

Dionysus :: Ancient Rome Roman History

Dionysus Dionysus, also known by his Roman name Bacchus, which he appears to have two different origins. Dionysus was the god of wine, agriculture and fertility of nature, but on the other hand he also represents the mystery in religions. Scholars believe that this god came about later in pre-history, unlike other gods. Almost all barbarian nations had their own versions of Dionysus under many names such as, Bacchus, Zagreus, Sabazius, Adonis, Antheus, Zalmoxis, Pentheus, Pan, Liber Pater, or simply "the liberator." His symbol was the thyrsus, (which is a staff tipped with a pinecone, sometimes with ivy leaves) Dionysus was born of fire, he was good and gentle to those who honored him, but he also brought madness and destruction to those who ignored him or the rituals of his cult. "One day, Zeus was traveling on Earth. He wore a disguise; because undisguised no mortal could look at him and live. He came to Thebes, and Ancient City of Greece where he fell in love with Semele, the daughter of King Cadmus. Their love was immense, and before they knew she became pregnant. Semele wanted nothing else but to look into the eyes of her true love. Her nurse, who happened to be the disloyal Hera in disguise, influenced her cruelly. Semele could not stand it any longer and finally, she asked Zeus to give her a good fortune. He was deeply in love with the young women and did anything she pleased. He swore an unbreakable promise on the river Styx that she could have anything she wished for. Meaning no harm, Semele asked to see the god of thunderbolt, Zeus was frightened. He knew that this would mean her guaranteed death. "NO" he cried in torment. "Anything but that. You do not know what you're asking for." She insisted and Zeus miserably kept his word and granted her wish. As he reveled his burning appearance, the unlucky Semele was almost completely destroyed by the fire, except her womb, which she had wrapped with some ivy. Zeus was angry, he quickly took the fetus from the womb, cut open his own thigh, and put the child into it. The child continued to grow in Zeus's thigh, when development in the womb was complete, Zeus gave birth to the baby, Dionysus. The child of fire had been born with a brand new force to be discovered.

Poetry Comparison Compare Blake’s ‘London’ and Wordsworth’s ‘Composed upon Westminster Bridge’ Essay

The two poems ‘London’ and ‘Composed upon Westminster Bride’, offer differing views on the city of London. Blake presents London as lifeless, dismal and monotonous, whereas Wordsworth’s London is very different. He feels it as beautiful, magnificent and exciting. Blake’s poem consists of four different stanzas all of equal length. This gives a sense of order and regularity. This demonstrates that the people of London live a controlled life, which has no variety. Blake uses repetition, which gives a sense of anguish, ‘And mark in every face I meet, Marks of weakness, Marks of woe’. This stresses the tedious pace of life. Blake also shows that the people of London are trapped in themselves, ‘In every voice, in every man, the mind forged manacles I hear’. This demonstrates that the people of London cannot express themselves as they are trapped in their own minds. Blake’s London shows the poets anger towards some members of the community. Blake blackens the city by painting images of child labour, ‘how the chimney sweepers cry; every blackening church appals’. This shows that the church is a hypocrite as they are using chimneysweepers themselves. Blake also dislikes the rich aristocrats by describing ‘how the hapless sigh, runs in blood down the palace walls’. This emphasises that the poor work very hard and fight pointless battles while the rich reap the rewards and benefits. In stanza four Blake paints a disgusting picture of prostitution, ‘the youthful harlots curse, blasts the newborn infants ear’, this tells the reader that prostitution leads to disease and plagues, many unwanted. Married men spilt up with their wives. Prostitutes have children, so the cycle continues for years. Blake combines ideas of ‘marriage and hearse’, this to show that the life cycle for people in London is death and suffering. Also Blake horrifies the reader by using different sounds to describe the feelings of people who live in London. He describes ‘moans’ and ‘cries’ to show the reader the depression of the people in London. The city of London is full of sorrow for every man and every infant ‘every cry of every man, in every infants cry of fear’. Also it is very negative and everyone feels depressed ‘harlots curse†¦ soldiers sigh’. Blake intensifies this gloomy atmosphere further, by using iambic meter in his poem. The use of iambic meter and an (ABAB) rhyming scheme for example ‘street†¦flow†¦meet†¦woe’, illerates to the reader how monotonous everyday life in London is, ‘I wandered though each chartered street’. The fact that Blake is wandering through London suggests that the city is boring and has no aims or direction. The reader can work out that Blake is blaming his apathy on the city itself and perhaps it is London’s fault that the population has ‘marks of woe’. Blake’s poem is clearly written about life in the slums of London, while Wordsworth, in his sonnet ‘Composed Upon Westminster Bridge’ focuses on a more general way on the majesty and splendour of London. Wordsworth was a nature lover who normally didn’t like the cities but in the early morning he sees something wonderful and glorious about London. Wordsworth realises that this moment is only temporary ‘never did the sun more beautifully steep in his first splendour, valley, rock or hill’. It was pollution less city bright and splendid. Nothing evil dark or dismal like Blake’s London. ‘This city now doth like a garment wear’, it demonstrates that it is an out of this world experience. He personifies the city, bringing it to life, in order to show how this is a transient moment. Wordsworth also respects the city for its beautiful buildings, unlike Blake who sees it as a city of degraded humanity noting the ‘harlot’s curse’. Wordsworth sees many beautiful ‘towers, domes, theatres and temples†¦ open into the fields and to the skys’. This shows the stillness and emptiness. This is a laying affect to show that man made objects can be as good as nature, unlike Blake who sees misery. Wordsworth uses a very calm and tranquil tone to describe London. This poem is written in the firm pentrarchian sonnet, with iambic pentameter utilises an (ABBA, ABBA, CDCD) rhyme scheme unlike Blake’s continuous (ABAB) rhyme scheme. This creates an unhurried pace with a peaceful mood lacking the intensity of Blake’s poem. It also provides a slow pace to take in the beauty of London in the early morning. Wordsworth’s surprise at the beauty of London is seen when he directly addresses ‘Dear God’! Using an exclamation mark, Wordsworth address God twice to stress his personal reaction to London’s beauty-he wants the reader to see the awe of London, the exclamation mark stresses the shocked pleasure by his reaction. The ‘mighty heart’ demonstrates that the people are the heart of the city-sees London as alive and living part of city working together. Wordsworth values people, as they are the centre point of London. Wordsworth tries to tell the reader that the Thames is working in harmony with the rest of the city. However, although the imagery of London Blake creates through its depressed state and ‘every cry of every man’. In my opinion I prefer Wordsworth’s poem ‘Composed Upon Westminster Bridge’, because he uses personification and makes the city feel beautiful. He states how ‘dull of soul’ anyone would be if they didn’t admire the beauty of London in the early morning. The way Wordsworth describes the cities buildings has a positive effect on the poem and this is why I prefer ‘Composed Upon Westminster Bridge’.

Ethics of Offshoring Novo Nordisk

Critical issued of the appropriateness of conducting clinical trials in emerging countries has arisen over years. Being a leading company in biopharmaceutical industry, Novo Nordisk faces the critiques of whether it is justice to offshoring their clinical trials in developing economies. With the consistency of ethical principles brought up by Novo Nordisk, the company would be able to move their trials into emerging economies with the best interest for stakeholders. I will also propose ideas to Mr, Dejgaard for possible approach to media as well as the practices that Novo Nordisk could have changed over time at the end. Conducting Clinical Trials in Emerging Economies With Utilitarian approach, every party has different perspectives in the outcome of an action. In this case, we have shareholders, employees, customers, supply chain, government and local communities, with secondary stakeholders of media, special interest groups and NGOs. For customers, government and local communities, they emphasize more on the proof of efficacy and safety of medical products. While shareholders, employees, supply chain care more of the profitability as a whole in general. As a result, Novo Nordisk will be better off maximizing its profits while holding their ethical justice for conducting clinical trials in emerging countries. Economic Aspect As the Nobel prize winner, Milton Friedman pointed out that making profit will be the first priority for business to fulfill social responsibility, Novo Nordisk has every right to maximize its best interest for its stakeholders include shareholders, employees, customers, suppliers, governments and local communities. From financial performance stand point, conducting clinical trials in emerging economies benefits Novo Nordisk from saving costs, accessing to larger demographic participant, obeying less strict rules applied, and establishing efficacy in different environmental onditions. Ethical Aspect On the other hand, firms should consider the corporate social responsibility brought by the society. Firms definitely need to incorporate their highest moral standards to build trust and reputation for themselves in order to better off in long run. Novo Nordisk always follows the regulation from Helsinki Declaration with other international ethical guidelines. They made sure that the inte rest and well-being of the trial subject should always transcend over the interest of science, society and commerce. Decision Principles Even though I think conducting clinical trials in emerging economies is beneficial to the firm, Novo Nordisk should still follow below guidelines for this major decision to protect its own reputation and serve the best interest for every stakeholder: †¢ Execute clinical trials when the internal organization is well established and external environment is proper regulated in emerging countries. †¢ Conduct placebo clinical trials when they are scientifically and ethically justified. †¢ Ensure the human rights of the participants in emerging countries associated with the predictable risks Responses to The Media I understand that Mr. Dejaard holds a high ethical stands, and is not interested in misleading the public or ethical dissembling in the response. It is also important to clear up the actions Novo Nordisk has taken for the past years and give public a clear picture of how the firm is operating. If a journalist is inviting for an interview, Mr. Dejaard should present himself into the public and response to the inquiry people have, otherwise, absence will only show irresponsible image that he might try to escape from the issue. Medical Ethics I will suggest Mr. Dejaard to pull out historical data indicating that the random checks investigated from Food and Drug Administration (FDA), the American and European authorities have never identified ethical problems in clinical trials in emerging economies. Second, assert the ethic codes from their company will help the publics to receive the image of Novo Nordisk has complied with the Helsinki Declaration of the World Medical Association. Ethical Business Media might inquiry the fairness of conducting placebo experiment in emerging countries by Novo Nordisk based on the industry trends in recent time. Mr. Dejaard could response to them that Novo Nordisk usually stay away from placebo trials, and only used in phase 1 trials which only healthy volunteers participated. Also, Novo Nordisk framed new business ethics policy in 2005 with generally accepted high standards while training managers and employees attending workshops and offering e-learning policy. To better respond to the media, Mr. Dejaard could also indicate that Novo Nordisk will try to implement some new action plan that could benefit stakeholders as a whole in order to minimize ethical conflicts. I suggest the following action plan for Novo Nordisk to benefit them in long run. Action Plan Enhance Auditing System To build trust for the stakeholder for Novo Nordisk, I believe the firm should develop a more solid auditing system. Instead auditing 10% of all trials, Novo Nordisk should increase the rate up to 50% or more. From a public view, 10% of investigating in all trials is not sufficient enough to prove that the trials are ethical conducted. With the increasing number of trials being audited and investigated, the quality of the clinical trials could be better controlled. Build up Placebo Experiment Standard In the â€Å"Clinical Trials: Novo Nordisk’s Position,† it pointed out that placebo will only be used as comparator when scientifically and ethical justified. It is quite unclear for public to know what would be an appropriate placebo experiment for Novo Nordisk to conduct while proven therapy is available. It is important to insiders to identify whether or not conducting placebo experiment under certain circumstances will have any additional risk and irreversible harm.

Rear Window

Lauren Riley Professor Piana February 26, 2012 Rear Window Last class we viewed the film called Rear Window. The main plot behind this film is the main character, Jefferies, has a broken leg therefore he has to spend 6 weeks in a wheelchair in his apartment. The one form of entertainment he has is to window watch all his neighbors. Jefferies has a girlfriend named Lisa but tells his nurse that he does not want to marry her. After a few weeks Jefferies catches onto his neighbors business. He seems to think one of his neighbors named Thorwall murdered his wife.He gets this perception from weapons being brought into the apartment and a random disappearance of his wife, while some of her belongings stay at the apartment. From here he spends the rest of his time trying to solve this â€Å"murder† mystery. He gets help from his girlfriend, a friend and his nurse. Towards the end of the movie the action increases dramatically. Lisa sneaks into Thorwall’s apartment to look for evidence of the murder. While she is in their Thorwall comes back and finds her in his apartment and begins to beat her. The police are then called and Lisa is brought to jail for trespassing.Next Thorwall sneaks into Jefferies apartment and begins to beat him up even though Jefferies is helpless because of his leg. He then pushes him out the window and survives but then breaks his other leg and has to go 6 more weeks’ window watching in his apartment. Important scenes play a big role in films. The first important scene is when Jefferies first discovers Thorwall’s wife is gone. This is when he comes up with the idea of the murder. This is the scene that begins the conflict in the film. Another important scene is when Lisa sneaks into Thorwall’s apartment and gets caught. This scene is the climax of the film.A final important scene is when Lisa is let out of jail and the policeman catch Jefferies out of the window and he breaks his other leg, this shows irony and a predicted future for him. Throughout films we see repeated elements. First we see girls wearing dresses. Back then girls were always dressed nicely. This is repeated throughout the whole film. A big element repeated is when Thorwall leaves his apartment 3 different times during one night when it was rainy out. He has his suitcase with him every time as well. This portrayed the first image of suspicion. Another repeated prop was binoculars.This was important because it helped them figure out the murder case and was an essential tool in this film. This film portrayed neighborly conflict. As we have seen in prior films, everyone must love they neighbor. I believe this was broken in this film. First we see someone’s dog was killed and she immediately starts blaming and asking which neighbor killed her dog. Another time where we don’t see loving neighbors is when Thorwall uses violence against Lisa and Jefferies. Respect for neighbors was not followed in this film. Withi n this film we see a lot of marital and serious relationships.We are portrayed with the image that the girl cooks dinner for the man every night and sets up a nice table and helps him relax after a long days of work. Unfortunately Jefferies sees a lot of this, but continues to believe in not marrying Lisa. Towards the end of the movie though his perspective changes. It shows Lisa and Jefferies happily relaxing in his apartment together. Within this film Hitchcock used Montage editing. This was a new concept back then and Hitchcock did a fantastic job using it. We saw frames from lots of different angels and frames put in order to create meaning.

Writing the Memo

WRITING AN OFFICE MEMORANDUM If you work as a paralegal or law clerk after your first or second year of law school, you will most likely spend some of your time researching and writing objective memoranda, or interoffice memos. Typically, an attorney asks you to provide a realistic analysis of the law as it applies to the facts of a client’s case. The purpose is to inform – not persuade. Although you should remember which conclusion favors your client, also keep in mind that you will represent the client most effectively by being objective and realistic.The memo might be read many times – possibly, over a period of months or years by several different attorneys, including the writer, who may use it as a resource long after it is drafted. The attorney will use the information contained in the memo to advise the client and may use it to prepare a document that will ultimately be filed in court. For example, a partner may be asking you whether a particular client ha s a valid legal claim. If you conclude that the answer is â€Å"yes,† then this will probably turn into a lawsuit. At that point, some parts of the memo may be incorporated when the complaint is drafted.The memo might me consulted a third time when the attorney responds to a motion to dismiss; a fourth time while drafting interrogatories; a fifth time before making a motion for summary judgment; a sixth time before trial; and a seventh during an appeal; and so on. PARTS OF MEMO[1] 1. A memorandum heading 2. The Issue (sometimes called Question Presented) states the question(s) that the memorandum resolves. The Issue also itemizes the few facts that you predict to be crucial to the answer. (Such as travel expenses to out-of-state, keeping child out of danger, and commission of crime).The reader should understand the question without having to refer to the facts. 3. Brief Answer (sometimes called Conclusion) states the writer’s prediction and summarizes concisely why it is likely to happen. Some writers begin with a direct response such as â€Å"yes† or â€Å"probably not. † Our book says that they do not prefer this. Sometimes this is client or partner driven. Also, some questions lend themselves to answers such as â€Å"yes† or â€Å"no. † Allusion to determinative facts and rules. Do not omit key facts. Begin by just re-stating your issue as a declarative sentence. Do not omit the reasoning.Do not include citation to authority or application of relevant law. Many attorneys only read this part. 4. Facts set out the facts on which the prediction is based. 5. Discussion is the largest and most complex part of memo. It proves the conclusion set out in brief answer. If the discussion is highly detailed or analyzes several issues, it should be broken down into subheadings. Here is what the memo will look like and more information on each section. MEMORANDUM TO:Senior Partner [Please block-indent so that the information line s up, as demonstrated] FROM:Your Name DATE:(date assignment is submitted)RE:(A concise label for the issue considered: mention the parties; your firm will file your Memo by names and cause of action–and, perhaps, by jurisdiction) The proper format is always double-spaced. Do not double-double space between sections. Plain old, regular double-space is sufficient. FACTS Here, recite all material facts, usually in chronological order. A â€Å"material† fact is a â€Å"dispositive† fact, or one upon which the outcome will depend. It is a fact that will affect the outcome in one way or another. Please include all material procedural facts as well as all material substantive facts.This means that it is essential to include all relevant times, dates, and places. You should begin with an â€Å"overview† sentence that sets the full context and begins to describe the problem presented. Please review your reading and as many samples as possible to understand both th e range and scope of what is acceptable as professional practice. Remember your role Watch for the tendency to try to â€Å"prove† something by the way you tell the story. NO LEGAL ANALYSIS! 1) USE NEUTRAL LANGUAGE AND OBJECTIVE CHARACTERIZATIONS. Rather than writing â€Å"the D was speeding through the school zone,† write â€Å"the D was traveling 50 MPH through the school zone. Rather than writing â€Å"The D brutally beat the victim,† write â€Å"The D struck the P on the head, resulting in a cut over his left eye. † 2) Include unfavorable and favorable facts. QUESTION PRESENTED Phrased as a question and ending with a question mark, state the specific issue or issues you will address. One method is to use the technique: under? (describe the law); does? (state the issue); what? (give the legally relevant or â€Å"dispositive† facts). Some memoranda use the commonly seen style of: â€Å"Whether . . . .† As always, discuss with your profess or to see which he or she prefers.But whatever the method, the following advice applies: †¢ Should be concise single sentences that include relevant facts and general propositions of law. †¢ Don’t say, â€Å"Whether a niece can recover for negligent infliction of emotional distress,† when you can say, â€Å"Whether, under Iowa law, a niece who witnesses the aftermath of an automobile accident involving her uncle from a block away can recover for negligent infliction of emotional distress when she observes his severe injuries upon arrival at the scene. † BRIEF ANSWER You phrased (or asked) a question in the section above. Answer it here: â€Å"Yes. † â€Å"No. â€Å"Probably not. † Use a period. Your Brief Answer follows the same formula and sequence as your Question Presented. It answers the questions â€Å"under? does? what? † except, the Brief Answer should include a brief statement of your reasons beginning with the word  "because. † DISCUSSION The heart of a Memorandum, this section asks you to explain the law and explain the facts. Getting it â€Å"right† will take time. Be patient. Your goal is to â€Å"synthesize† the cases and extract a common rule of law. To do this, you will need to identify the common elements that allow you to analyze and discuss several cases at once.A common mistake, legal writers frequently engage in â€Å"listing behavior. † They treat each case independently and sequentially, beginning each paragraph with â€Å"In†Ã¢â‚¬â€œfor example, â€Å"In Callow v. Thomas† or â€Å"In Brown v. Brown. † Looking down a written page, the lawyer will see a ladder-like effect, the â€Å"in-ladder,† where each succeeding paragraph begins with the word â€Å"in† followed by a case title. Often â€Å"listing behavior† culminates in â€Å"dump-trucking† when the lawyer saves up and â€Å"dumps† all the legal analysis into the last paragraph.In addition, lawyers will frequently â€Å"front-load,† squeezing all the legal rules of law into the very first paragraph. To avoid these pitfalls, begin your discussion with a general overview in a thesis or â€Å"roadmap† paragraph. Your thesis paragraph is the first paragraph in the Memorandum – and the first paragraph in a Discussion section. Always begin your thesis paragraph with a sentence to anticipate–and announce–your ultimate conclusion. Tell the reader where you are headed and be a tour-guide to your argument or analysis. Then, taking one point at a time, write a thesis sentence that answers the questions of â€Å"what-is-your-point? of this particular paragraph. Next, set forth the legal Rule that applies. Include the proper citation. Next, Analyze (explain) what the law or legal rule means. Next, Analyze (explain) how the relevant facts fit (or do not fit) the legal or factual standard. Finally, Conc lude each paragraph with a summarizing statement and each sub-issue with a specific sub-issue summary. Sometimes, this method is referred to as a variation of the acronym: IRAC. Other legal writing professors have some other acronym such as REAAC or FIRAC. Still, others simply refer to it as the 5-step process. Keep in ind that these are all â€Å"formulas† that legal writing professionals are using to introduce you to presenting a legal argument. Ultimately, you will use a style or formula that works best for your particular argument. But virtually every aspect of every legal argument must contain a 1) Statement of Rule or Applicable Law; 2) Analysis of the law and how it Applies to your relevant facts; and 3) a Conclusion on each of these sub-issues. Similarly, when a discussion requires several paragraphs, the writer may not reproduce the exact IRAC structure within each and every paragraph, but may require several paragraphs to develop fully the full set.As always, know y our audience and talk about the method of legal analysis that your professor, or in the future, your employer, prefers. And remember that learning how to synthesize statutes, cases, and secondary sources and then presenting them in a clear, concise, and logical manner takes time and practice. A FEW IDEAS ABOUT WRITING — MEMORANDA[2] Many students, approaching memo writing for the first time, are often unsure of how to proceed. We have put together a few tips for first (and second and third) time memo writers that we hope will be helpful.Note: No single set of guidelines could possibly address all the matters related to memo writing. If you have questions about a particular assignment, be sure to check with your professor. 1. Find the test(s). In assigning a memorandum, professors are generally evaluating you on parsing a particular statute or test. In other words, they want you to use other cases to explain how your case either does or does not satisfy a test laid out in a ca se or a statute. For example, let’s say your case involves a niece (Mary) who witnessed her uncle (Jack) being injured in an automobile accident.Mary wants to bring suit for negligent infliction of emotional distress as a result of witnessing that accident. In Burger v. McDonald, the Supreme Court of Iowa laid out a three part test to determine whether a bystander’s injury was reasonably foreseeable and, thus, legally actionable: 1. Whether the bystander was located near the accident. 2. Whether the injury resulted from sensory and contemporaneous observance of the accident, as opposed to hearing about it from others after its occurrence. 3. Whether the bystander and the victim were closely related.NOTE: If the memo involves more than one issue, your memorandum may involve more than one test. 2. Use the test as your outline. Tests come in two parts, or three (as above), often with subsections. Ideal for an outline. Use the major parts of the test as your major points, the subparts as sub-sections. Paragraph Structure 3. Begin paragraphs with affirmative propositions that parallel the test. In the above example, your first sentence should say something like: â€Å"Mary was located near the scene of her uncle’s accident, satisfying the first part of the Burger test. † 4.Support your affirmative propositions. All propositions of a legal nature must have legal support. Where is your authority for your proposition? Cite it. For example: â€Å"See Burger, 606 N. W. 2d at 321 (bystander must be located near accident to recover for negligent infliction of emotional distress). † 5. Discuss the facts of your support. What happened in the case you just cited? Explain in a concise and relevant way. For example: â€Å"In Burger, the court held that a mother who witnessed an accident on the street from the front door of her house was located near the scene of an accident. 6. Discuss the relevant facts of your case. Point to the facts that are similar to the facts of the authority you’ve just discussed. For example, you could continue from above as follows: â€Å"Mary was standing a block from the accident, heard the crash, and saw her uncle being pulled, bleeding, from the car. † 7. Analogize/Conclude. What conclusions do you think the court will draw from the similarity between your facts and the facts of your authority? For example: â€Å"Although Mary did not see the accident, she was close enough to hear it and witness her uncle being pulled from the car.Thus, a court will likely conclude that she was located near the accident. † Alternative Paragraph Structure 8. Discuss other relevant authority. Once you’ve opened the previous paragraph with your affirmative proposition, your subsequent paragraphs can discuss the facts of other relevant cases without repeating the proposition as your opening sentence. For example, you could begin the next paragraph: â€Å"In Cameron v. Jones, the C ourt of Appeals held that a mother who was twenty-five feet away from her child when she heard a metal sculpture fall on him was located near the scene of the accident. 9.Discuss contrary authority. Are there cases that go against your position (or the position the partner/judge/etc. would like you to hold)? Another subsequent paragraph could open with: â€Å"But, in Alfred v. Stern, the court held that a father did not have a valid cause of action for negligent infliction of emotional distress. † Then follow steps 5, 6, and 7, above, except this time, when concluding, tell the reader why the court won’t follow or give much weight to this contrary authority (e. g. , the facts are different). 10. Move on to the next part of the test. Follow steps 3-9 above for the next section of your test.Remember, a memorandum also includes issues presented, a brief answer (which usually follows the issues presented), and a statement of facts. These are often best written after youâ⠂¬â„¢ve written the body of the memorandum, since you’ll have a better idea of the issues once you’ve tackled the problem (though a tentative draft might help to get you started). Here is a checklist for those introductory sections of an office memorandum: Heading 1. Have you included the name of the requesting attorney (or professor), your name, the date, the client’s name, and a phrase identifying the particular legal matter or issue?Facts 2. Have you included all legally significant facts? 3. Have you included sufficient factual context? 4. Have you included any major emotional facts? 5. Have you avoided including discussion of legal authority? 6. Have you avoided â€Å"arguing† the facts or drawing legal conclusions? 7. Have you identified the client and the client’s situation at the beginning of the Fact Statement? 8. Have you selected an appropriate organization (chronological, topical) for the facts? 9. Have you maintained neutral language a nd objective characterizations? 10.Have you included both favorable and unfavorable facts? Question Presented 11. Have you stated the legal question and the significant facts? 12. Have you edited to achieve one readable sentence? 13. Have you maintained an objective perspective? Brief Answer 14. Have you stated the answer in the first several words? 15. Have you included a statement of the rule? 16. Have you stated a summary of the reasoning leading to the answer? 17. Have you kept the BA to a maximum of one-third to one-half a double-spaced page? 18. Have you taken a position, even if you are not sure? ———————– 1] Be sure to keep in mind that an office memo is an internal document for law firms; therefore, each particular firm is likely to have a preferred format. For example, the firm may use different words for different sections title, may order sections differently than described here, or it may include other sections not described in this manual. If your reader (whether it be your professor or your employer) has a preferred format, obviously use it. If you are not sure if your reader has a particular preference, then ask! [2] Many of these tips were originally created by Writing Resource Center, University of Iowa College of Law.